Integrating technologies: Ultrasound and cfDNA screening in twin pregnancies
Authors:
Vanessa Nitibhon, MS, CGC, Senior Medical Science Liaison, Labcorp Women’s Health and Genetics
Alan E. Donnenfeld, MD, FACOG, FACMG, Medical Director, Labcorp Women's Health and Genetics
Despite overall limited data on cell-free DNA (cfDNA) testing in twin gestations, MaterniT 21 PLUS has demonstrated high sensitivity and specificity in screening for trisomy 21 in twins from the first trimester of pregnancy (comparable to that observed in singleton pregnancies), as well as promising performance in screening for trisomies 13 and 18, according to the results of a newly published study.1 Hear from our experts about the nuances of twin pregnancy care as we combine ultrasound expertise with the latest research review on fetal cfDNA screening.
References
- Dugoff L, Koelper NC, Chasen ST, et al. Cell-free DNA screening for trisomy 21 in twin pregnancy: a large multicenter cohort study. Am. J. Obstet. Gynecol. 2023. doi:10.1016/j.ajog.2023.04.002.