Allergen Profile, Pediatric, IgE With Component Reflexes

CPT: 82785; 86003(x24); 86008
Updated on 01/8/2025
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Test Includes

Alternaria alternata; Brazil nut; Candida albicans; cashew nut; cat dander; cedar; codfish; cockroach, German; Dermatophagoides pteronyssinus; dog dander; egg white; hazelnut (filbert); immunoglobulin E, total; milk; mouse urine; peanut (whole); salmon; scallop; sesame seed; shrimp; soybean; timothy grass; tuna; walnut; wheat; w5-gliadin (tri-19)

• If milk IgE ≥ 0.35 kU/L, reflex tests α-lactalbumin, β-lactoglobulin and casein will be added.

• If egg white IgE ≥ 0.35 kU/L, reflex tests ovalbumin and ovomucoid will be added.

• If sesame IgE ≥ 0.10 kU/L, reflex test Ses I 1 will be added.

• If walnut IgE ≥ 0.10 kU/L, reflex tests Jug r 1 and Jug r 3 will be added.

• If hazelnut (filbert) IgE ≥0.10 kU/L, reflex tests Cor a 1, Cor a 8, Cor a 9 and Cor a 14 will be added.

• If cashew nut IgE ≥ 0.10 kU/L, reflex test Ana o 3 will be added.

• If Brazil nut IgE ≥ 0.10 kU/L, reflex test Ber e 1 will be added.

• If peanut (whole) IgE ≥ 0.10 kU/L, reflex tests Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8 and Ara h 9 will be added.

• If wheat IgE ≥ 0.10 kU/L, one or more of the following components may be tested: Gliadin, Tri a 14 (wheat nsLTP), Phl p 12 (Timothy grass profilin) and/or Cross-reactive Carbohydrate Determinant (CCD).

• If cat dander IgE ≥0.35 kU/L, reflex tests Fel d 1 IgE, Fel d 2 IgE and Fel d 4 IgE will be added.

• If dog dander IgE ≥0.35 kU/L, reflex tests Can f 1 IgE, Can f 2 IgE, Can f 3 IgE and Can f 5 IgE will be added.


Expected Turnaround Time

4 - 6 days

3 - 5 days

4 - 6 days



Related Documents

For more information, please view the literature below.

Food Allergy Testing Brochure


Specimen Requirements


Specimen

Serum


Volume

4 mL


Minimum Volume

3 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

If a red-top tube is used, transfer separated serum to a plastic transport tube.


Storage Instructions

Room temperature


Stability Requirements

TemperaturePeriod
Room temperature14 days
Refrigerated14 days
Frozen3 months
Freeze/thaw cyclesStable x3

Test Details


Use

This panel is designed to measure the extent of allergen sensitization in children and adolescents.


Methodology

Thermo Fisher ImmunoCAP® Allergen-specific IgE


References

Belgrave DC, Granell R, Simpson A, et al. Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies. PLoS Med. 2014 Oct 21;11(10):e1001748.25335105
Casale TB, Pedersen S, Del Rio PR, Liu AH, Demoly P, Price D. The Role of Aeroallergen Sensitization Testing in Asthma Management. J Allergy Clin Immunol Pract. 2020 Sep;8(8):2526-2532.32687905
Chang TS, Lemanske RF Jr, Guilbert TW, et al. Evaluation of the modified asthma predictive index in high-risk preschool children. J Allergy Clin Immunol Pract. 2013 Mar;1(2):152-156.24187656
Fabiano Filho RC, Geller RJ, Santos LC, et al. Performance of Three Asthma Predictive Tools in a Cohort of Infants Hospitalized With Severe Bronchiolitis. Front Allergy. 2021 Oct 22;2:758719.35387011
Guilbert TW, Morgan WJ, Zeiger RS, et al. Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol. 2004 Dec;114(6):1282-1287.15577824
Gupta RS, Warren CM, Smith BM, et al. The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States. Pediatrics. 2018 Dec;142(6):e20181235.30455345
Savage J, Sicherer S, Wood R. The Natural History of Food Allergy. J Allergy Clin Immunol Pract. 2016 Mar-Apr;4(2):196-203; quiz 204.26968958
Sicherer SH, Sampson HA. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018 Jan;141(1):41-58.29157945
Sicherer SH, Sampson HA. Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 2014 Feb;133(2):291-307; quiz 308.24388012
Sicherer SH, Warren CM, Dant C, Gupta RS, Nadeau KC. Food Allergy from Infancy Through Adulthood. J Allergy Clin Immunol Pract. 2020 Jun;8(6):1854-1864.32499034

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