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Adoptive Cell & CAR T-Cell Therapies

With over 80 unique hematological malignancy cell lines, such as the CD19+ Raji-Luc lymphoma model, the MV-4-11-Luc-mCh-Puro leukemia model, and the MM.1S-Luc-Neo multiple myeloma model, we lead the industry with market-relevant models for your studies. Nous proposons également une liste toujours plus grande de modèles de tumeurs solides validés sur des souris NSG pour soutenir les efforts du domaine en vue de l'approbation d'une thérapie cellulaire adoptive (ACT) dans une indication de tumeur solide.

Discover an unparalleled breadth of experience in the use of mouse tumor models to evaluate ACTs.

With a broad range of disseminated and subcutaneous tumor models characterized in NSG mice, and a scientific team that knows how to apply them, we can guide selection of the right tumor model for your Chimeric Antigen Receptor (CAR) T-cell study or other ACT study.

Tumor Models by Histotype, Characterized in NSG Mice

 

HistotypeModèle
Acute monocytic leukemiaMV-4-11-Luc-mCh-Puro (disseminated)
THP1-Luc-mCh-Puro (disseminated)
Burkitt's lymphomaDaudi-Luc-mCh-Puro (disseminated)
Raji-Luc (SC/disseminated)
Leucémie lymphoblastiqueNALM6-Luc-mCh-Puro (SC/disseminated)
Leucémie myéloïdeKasumi-3-Luc-mCh-Puro (disseminated)
KG-1-Luc-mCh-Puro (disseminated)
Myélome des cellules du plasmaMM1.S-Luc-Neo (disseminated)
MOLM-13 (disseminated)
NCI-H929-Luc-mCh-Puro (disseminated)
RPMI-8226 (SC)
Promyelocytic leukemiaHL-60-Luc-mCh-Puro (disseminated)

 

 

HistotypeModèle
Bladder carcinomaSW780 (SC)
Breast/mammary carcinomaBT-474 (SC)
HCC70 (SC)
MDA-MB-231 (OT)
MDA-MB-231-Luc-D3H2LN
MDA-MB-468 (SC)
ZR-75-1 (SC)
Carcinome gastriqueNCI-N87 (SC)
SNU-5 (SC)
GlioblastomeU-251-Luc-mCh-Puro (SC/intracranial)
Carcinome hépatocellulaireHep 3B2,1-7 (SC)
Hep G2 (SC)
Hypopharyngeal squamous cell carcinomaFaDu
Lung cancer: Non-small cell lung carcinomaA549 (SC)
Calu-3
NCI-H1299 (SC)
NCI-H1703 (SC)
NCI-H1975 (SC)
NCI-H1975-Luc (SC)
Lung cancer: Small cell lung carcinomaDMS-114 (SC)
NCI-H446 (SC)
NCI-H82 (SC)
SHP-77 (SC)
MélanomeA-375 (SC)
SK-MEL-28 (SC)
Ovarian carcinomaOV-90 (SC)
OVCAR-8-Luc-mCh-Puro (SC/IP)
PA-1 (SC)
SK-OV-3 (SC)
SK-OV-3-Luc-D3 (IP)
Pancreatic ductal adenocarcinomaBxPc-3 (SC)
MIA PaCa-2 (SC)
Carcinome de la prostate22Rv1 (SC)
LNCaP clone FGC (SC)
PC-3 (SC)
PC-3M-Luc-C6 (SC)

 

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