Fish Metabolism Studies and Their Potential Use in Environmental Safety Testing

SETAC North America 2022 -- With the increasing popularity of fish-based diets, a large proportion of fish we eat comes from fish farms. The diet used in these farms often comprises a substantial portion of plant commodities, leading to a potential risk of exposure to pesticide residues. The European pesticide regulation requires fish metabolism and fish feeding studies where residues in fish feed exceed 0.1?mg/kg of the total diet (dry weight basis), hence enabling the setting of appropriate maximum residue levels in fish commodities. At Labcorp, we are using our extensive experience in conducting fish bioaccumulation studies (both aqueous and dietary exposure, OECD 305) and livestock nature of the residue studies (OECD 503) to establish strategies for overcoming the potential challenges of the fish metabolism study (SANTE/10254/2021 23 February 2021 Nature of pesticides residues in fish). Animal care and use is conducted in alignment with applicable animal welfare requirements. The