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Metastatic triple negative breast cancer has distinct tumor immune landscape

November 3, 2023

Metastatic triple-negative breast cancer (TNBC) exhibits increased inflammation and higher expression of checkpoint targets compared to non-TNBC cases, with a paradoxical finding that lower PD-L1 expression is associated with better overall survival. Our findings suggest the need for site-specific metastatic tumor analysis and consideration of immunotherapy in metastatic TNBC treatment.