Roadmap: Labcorp's approach to next generation risk assessment

SETAC NA 2023 -- Current approaches for the safety assessment of human health and environmental risks due to chemical exposure have heavily relied on using animal models. The approach has generally been conservative and as such there has been a reluctance to change the way we perform risk assessments. However, given the amount of chemicals in need of assessment and the additional endpoints needing testing, such as endocrine activity, there has been a global awareness of the need for a paradigm shift toward moving away from animal models to more scientifically relevant, hypothesis-driven testing.