Buprenorphine and Norbuprenorphine, Serum or Plasma

TEST: 070103
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CPT: 80299
Updated on 11/27/2024
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Synonyms

  • Buprenex®
  • Suboxone®
  • Subutex®
  • Buprenex®
  • Free Buprenorphine
  • Subutex®
  • Buprenex®
  • Suboxone®
  • Subutex®

Expected Turnaround Time

3 - 6 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Serum or plasma

Serum, plasma, or whole blood

Serum or plasma

Volume

3 mL

0.25 mL

3 mL

Minimum Volume

0.5 mL

Container

Red-top (no additive) tube or green-top (heparin) tube; gel-barrier tubes are not recommended

Red-top tube, lavender-top (EDTA) tube, gray-top (sodium fluoride) tube, or green-top (heparin) tube. Do not use a gel-barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.

Red-top (no additive) tube or green-top (heparin) tube; gel-barrier tubes are not recommended

Collection


Transfer separated serum or plasma to a plastic transport tube. Trough levels are most reproducible.

Separate serum or plasma within two hours of collection and transfer to a plastic transport tube.

Transfer separated serum or plasma to a plastic transport tube. Trough levels are most reproducible.

Storage Instructions

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.

Room temperature

Submission/transport (<3 days): Room temperature. For storage beyond three days, specimen should be refrigerated or frozen.

Stability Requirements

TemperaturePeriod
Room temperature14 days
Refrigerated14 days
Frozen14 days

Test Details

Use

This test is used for therapeutic drug management.

Buprenorphine is used in the management of moderate to severe chronic pain.

Half-life elimination: IV: 2.2 to 3 hours, Sublingual tablet: approximately 37 hours, Transdermal patch: approximately 26 hours

Time to peak plasma: Sublingual: 30 minutes to 1 hour

This test is used for therapeutic drug management.

Limitations

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Reference Interval

Buprenorphine: 1.00–10.00 ng/mL; norbuprenorphine: not established

Buprenorphine: 1.00–10.00 ng/mL; norbuprenorphine: not established

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