Allergen Profile, Food, IgE With Component Reflexes

CPT: 86003(x16); 86008
Updated on 10/8/2024
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Test Includes

This profile includes the nine major allergen groups associated with food allergy1-4 and their reflexes to components: almond; Brazil nut; cashew nut; codfish; egg white; hazelnut (filbert); milk; peanut (whole); salmon; scallop; sesame seed; shrimp; soybean; tuna; walnut; wheat and w5-gliadin (tri-19).

• If milk IgE ≥ 0.35 kU/L, reflex tests α-lactalbumin, β-lactoglobulin and casein will be added.

• If egg white IgE ≥ 0.35 kU/L, reflex tests ovalbumin and ovomucoid will be added.

• If sesame IgE ≥ 0.10 kU/L, reflex test Ses I 1 will be added.

• If walnut IgE ≥ 0.10 kU/L, reflex tests Jug r 1 and Jug r 3 will be added.

• If hazelnut (filbert) IgE ≥ 0.10 kU/L, reflex tests Cor a 1, Cor a 8, Cor a 9 and Cor a 14 will be added.

• If cashew nut IgE ≥ 0.10 kU/L, reflex test Ana o 3 will be added.

• If Brazil nut IgE ≥ 0.10 kU/L, reflex test Ber e 1 will be added.

• If peanut (whole) IgE ≥0.10 kU/L, reflex tests Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8 and Ara h 9 will be added.

• If wheat IgE ≥ 0.10 kU/L, one or more of the following components may be tested: Gliadin, Tri a 14 (wheat nsLTP), Phl p 12 (Timothy grass profilin) and/or Cross-reactive Carbohydrate Determinant (CCD).

This profile includes total IgE, the nine major allergen groups associated with food allergy,1-4 and their reflexes to components: almond; Brazil nut; cashew nut; codfish; egg white; hazelnut (filbert); milk; peanut (whole); salmon; scallop; sesame seed; shrimp; soybean; tuna; walnut; wheat; and w5-gliadin (tri-19).

• If milk IgE ≥ 0.35 kU/L, reflex tests α-lactalbumin, β-lactoglobulin and casein will be added.

• If egg white IgE ≥ 0.35 kU/L, reflex tests ovalbumin and ovomucoid will be added.

• If sesame IgE ≥ 0.10 kU/L, reflex test Ses I 1 will be added.

• If walnut IgE ≥ 0.10 kU/L, reflex tests Jug r 1 and Jug r 3 will be added.

• If hazelnut (filbert) IgE ≥ 0.10 kU/L, reflex tests Cor a 1, Cor a 8, Cor a 9 and Cor a 14 will be added.

• If cashew nut IgE ≥ 0.10 kU/L, reflex test Ana o 3 will be added.

• If Brazil nut IgE ≥ 0.10 kU/L, reflex test Ber e 1 will be added.

• If peanut (whole) IgE ≥0.10 kU/L, reflex tests Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8 and Ara h 9 will be added.

• If wheat IgE ≥ 0.10 kU/L, one or more of the following components may be tested: Gliadin, Tri a 14 (wheat nsLTP), Phl p 12 (Timothy grass profilin) and/or Cross-reactive Carbohydrate Determinant (CCD).

This profile includes the nine major allergen groups associated with food allergy1-4 and their reflexes to components: almond; Brazil nut; cashew nut; codfish; egg white; hazelnut (filbert); milk; peanut (whole); salmon; scallop; sesame seed; shrimp; soybean; tuna; walnut; wheat and w5-gliadin (tri-19).

• If milk IgE ≥ 0.35 kU/L, reflex tests α-lactalbumin, β-lactoglobulin and casein will be added.

• If egg white IgE ≥ 0.35 kU/L, reflex tests ovalbumin and ovomucoid will be added.

• If sesame IgE ≥ 0.10 kU/L, reflex test Ses I 1 will be added.

• If walnut IgE ≥ 0.10 kU/L, reflex tests Jug r 1 and Jug r 3 will be added.

• If hazelnut (filbert) IgE ≥ 0.10 kU/L, reflex tests Cor a 1, Cor a 8, Cor a 9 and Cor a 14 will be added.

• If cashew nut IgE ≥ 0.10 kU/L, reflex test Ana o 3 will be added.

• If Brazil nut IgE ≥ 0.10 kU/L, reflex test Ber e 1 will be added.

• If peanut (whole) IgE ≥0.10 kU/L, reflex tests Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8 and Ara h 9 will be added.

• If wheat IgE ≥ 0.10 kU/L, one or more of the following components may be tested: Gliadin, Tri a 14 (wheat nsLTP), Phl p 12 (Timothy grass profilin) and/or Cross-reactive Carbohydrate Determinant (CCD).


Expected Turnaround Time

3 - 5 days



Related Documents

For more information, please view the literature below.

Food Allergy Testing Brochure


Specimen Requirements


Specimen

Serum


Volume

4 mL


Minimum Volume

3 mL (Note: This volume does not allow for repeat testing.)


Container

Red-top tube or gel-barrier tube


Collection

If a red-top tube is used, transfer separated serum to a plastic transport tube.


Storage Instructions

Room temperature


Stability Requirements

TemperaturePeriod
Room temperature14 days
Refrigerated14 days
Frozen3 months
Freeze/thaw cyclesStable x3

Test Details


Use

This panel is designed to measure the extent of allergen sensitization in children, adolescents and adults.


Methodology

Thermo Fisher ImmunoCAP® Allergen-specific IgE


Footnotes

1. Sicherer SH, Warren CM, Dant C, Gupta RS, Nadeau KC. Food Allergy from Infancy Through Adulthood. J Allergy Clin Immunol Pract. 2020 Jun;8(6):1854-1864.32499034
2. Major Allergens: The Big Nine. School Nutrition Association (SNA) website: https://schoolnutrition.org/resource/major-allergens-the-big-nine/. Accessed January 2024.
3. Food Allergies. U.S. Food and Drug Administration website: https://www.fda.gov/food/food-labeling-nutrition/food-allergies. Accessed January 2024.
4. Food Allergy & Anaphylaxis. Food Allergy and Anaphylaxis Connection Team website: https://www.foodallergyawareness.org/food-allergy-and-anaphylaxis/food-allergens/the-top-9-foodallergens/. Accessed January 2024.

References

Gupta RS, Warren CM, Smith BM, et al. Prevalence and Severite of Food Allergies Among US Adults. JAMA Netw Open. 2019 Jan 4;2(1):e185630.30646188
Gupta RS, Warren CM, Smith BM, et al. The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States. Pediatrics. 2018 Dec;142(6):e20181235.30455345
Savage J, Sicherer S, Wood R. The Natural History of Food Allergy. J Allergy Clin Immunol Pract. 2016 Mar-Apr;4(2):196-203; quiz 204.26968958
Sicherer SH, Sampson HA. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018 Jan;141(1):41-58.29157945
Sicherer SH, Sampson HA. Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 2014 Feb;133(2):291-307; quiz 308.24388012

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