CHOP Oncology FISH

TEST: 510349
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CPT: Contact CPT coding department at 800-222-7566, ext. 6-8400.
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Contact CPT coding department at 800-222-7566, ext. 6-8400.
Updated on 10/17/2024
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Synonyms

  • Leukemia FISH
  • Lymphoma FISH

Special Instructions

There will be an additional charge for processing paraffin block samples or for samples that require culture.

Expected Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Specimen Requirements

Specimen

Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei, or bone marrow touch prep slides. Blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge.

Volume

Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube

Collection

Transport to the testing lab at room temperature; use a cool pack or LabCorp transport kit. Do not allow sample to freeze.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen

Test Details

Use

This test is used for confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas).

Confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas)

This test is used for confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas).

Methodology

Fluorescence in situ hybridization (FISH)

Additional Information

The CHOP break-apart FISH probe is designed to rule out a rearrangement of the gene located at 12q13 associated with a reciprocal (12;16)(q13;p11) translocation (CHOP-TLS gene fusion) and myxoid/round cell liposarcoma. CHOP is fused to TLS in about 90% of myxoid liposarcomas/round cell liposarcomas.

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